DESCRIPTION:

QTL Associated with Joint/bone inflammation. On Chromosome 1 with a LOD score= 5, p-value =. From a(n) F2 of DA/Bkl x F344/NHsd

LABEL:

QTL-Cia2-Rat-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Remmers EF, Longman RE, Du Y, O'Hare A, Cannon GW, Griffiths MM, Wilder RL

TITLE:

A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats.

JOURNAL:

Nature genetics None None, Vol 14, pp. 82-5

ABSTRACT:

1. Nat Genet. 1996 Sep;14(1):82-5. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers EF(1), Longman RE, Du Y, O'Hare A, Cannon GW, Griffiths MM, Wilder RL. Author information: (1)Inflammatory Joint Diseases Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892, USA. Identification of specific genetic loci that contribute to susceptibility to rheumatoid arthritis (RA) in humans has been hampered by several factors, including: i) multiple interacting genetic loci contributing to susceptibility; ii) complex interactions of environmental and genetic factors; iii) genetic heterogeneity; and iv) low penetrance. We have, therefore, mapped quantitative trait loci (QTLs) that control inflammatory arthritis susceptibility and/or severity in progeny of two inbred rat strains with significantly different susceptibilities to collagen-induced arthritis (CIA), an animal model for RA. Not surprisingly, we identified a major susceptibility factor, Cia1, on chromosome 20 in the vicinity of the rat major histocompatibility complex (MHC). However, by limiting the analysis to animals with arthritis-susceptible MHC genotypes and using genome-wide QTL analytic techniques, we also found four non-MHC QTLs-Cia2, 3, 4 and 5-on chromosomes 1, 4, 7 and 10, that contributed to disease severity. In addition, a QTL on chromosome 8 was suggestive for linkage. Characterization of the genes underlying these QTLs will facilitate the identification of key biochemical pathways regulating experimental autoimmune arthritis in rats and may provide insights into RA and other human autoimmune diseases. These genes may also represent novel targets for therapy. PMID: 8782824 [PubMed - indexed for MEDLINE] PUBMED: 8782824
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