DESCRIPTION:

QTL Associated with CD8 T cell CD45RC expression level. On Chromosome 20 with a LOD score= 5.7, p-value =. From a(n) of

LABEL:

QTL-Cdexp2-Rat-Chr 20

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Xystrakis E, Cavailles P, Dejean AS, Cautain B, Colacios C, Lagrange D, van de Gaar MJ, Bernard I, Gonzalez-Dunia D, Damoiseaux J, Fournié GJ, Saoudi A

TITLE:

Functional and genetic analysis of two CD8 T cell subsets defined by the level of CD45RC expression in the rat.

JOURNAL:

Journal of immunology (Baltimore, Md. : 1950) None None, Vol 173, pp. 3140-7

ABSTRACT:

1. J Immunol. 2004 Sep 1;173(5):3140-7. Functional and genetic analysis of two CD8 T cell subsets defined by the level of CD45RC expression in the rat. Xystrakis E(1), Cavailles P, Dejean AS, Cautain B, Colacios C, Lagrange D, van de Gaar MJ, Bernard I, Gonzalez-Dunia D, Damoiseaux J, Fournié GJ, Saoudi A. Author information: (1)Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 563, Institut Fédératif de Recherche (IFR) 30, Hôpital Purpan and Université Paul Sabatier, Toulouse, France. Differential cytokine production by T cells plays an important role in the outcome of the immune response. We show that the level of CD45RC expression differentiates rat CD8 T cells in two subpopulations, CD45RC(high) and CD45RC(low), that have different cytokine profiles and functions. Upon in vitro stimulation, in an Ag-presenting cell-independent system, CD45RC(high) CD8 T cells produce IL-2 and IFN-gamma while CD45RC(low) CD8 T cells produce IL-4, IL-10, and IL-13. In vitro, these subsets also exhibit different cytotoxic and suppressive functions. The CD45RC(high)/CD45RC(low) CD8 T cell ratio was determined in Lewis (LEW) and Brown-Norway (BN) rats. These two rat strains differ with respect to the Th1/Th2 polarization of their immune responses and to their susceptibility to develop distinct immune diseases. The CD45RC(high)/CD45RC(low) CD8 T cell ratio is higher in LEW than in BN rats, and this difference is dependent on hemopoietic cells. Linkage analysis in a F(2)(LEW x BN) intercross identified two quantitative trait loci on chromosomes 9 and 20 controlling the CD45RC(high)/CD45RC(low) CD8 T cell ratio. This genetic control was confirmed in congenic rats. The region on chromosome 9 was narrowed down to a 1.2-cM interval that was found to also control the IgE response in a model of Th2-mediated disorder. Identification of genes that control the CD45RC(high)/CD45RC(low) CD8 T cell subsets in these regions could be of great interest for the understanding of the pathophysiology of immune-mediated diseases. PMID: 15322174 [PubMed - indexed for MEDLINE] PUBMED: 15322174
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