DESCRIPTION:

QTL Associated with Lipid level. On Chromosome 10 with a LOD score= 3.3, p-value =. From a(n) of

LABEL:

QTL-Hpcl1-Rat-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Bottger A, Lankhorst E, van Lith HA, van Zutphen LF, Zídek V, Musilová A, Simáková M, Poledne R, Bílá V, Køen V, Pravenec M

TITLE:

A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet.

JOURNAL:

Biochemical and biophysical research communications None None, Vol 246, pp. 272-5

ABSTRACT:

1. Biochem Biophys Res Commun. 1998 May 8;246(1):272-5. A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet. Bottger A(1), Lankhorst E, van Lith HA, van Zutphen LF, Zídek V, Musilová A, Simáková M, Poledne R, Bílá V, Køen V, Pravenec M. Author information: (1)Department of Laboratory Animal Science, Veterinary Faculty, Utrecht University, The Netherlands. Liver cholesterol concentration in rats fed a high cholesterol diet, is under genetic control which is supported by significant differences observed among inbred strains. For instance, the Brown Norway (BN-Lx/Cub) rat developed a twofold higher liver cholesterol concentration than the spontaneously hypertensive rat (SHR/Ola). In the current study, we used 30 recombinant inbred (RI) strains, derived from BN-Lx and SHR progenitors, to locate quantitative trait loci (QTL) that are responsible for differences in liver cholesterol concentrations between the BN-Lx and SHR strains. The heritability of liver cholesterol was estimated to be 0.55 and a significant association was detected between concentration of liver cholesterol and the D10Cebrp1016s2 marker on chromosome 10 (lod score = 3.3); this putative QTL was responsible for nearly 64% of additive genetic variability and thus represents a major genetic determinant of liver cholesterol concentration. Liver cholesterol concentrations significantly correlated with intermediate density lipoprotein (IDL) cholesterol levels. PMID: 9600105 [PubMed - indexed for MEDLINE] PUBMED: 9600105
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