DESCRIPTION:

QTL Associated with Joint/bone inflammation. On Chromosome 19 with a LOD score= 5.8, p-value =0.001. From a(n) intercross of QTL Associated with Glucose level. On Chromosome 10 with a LOD score= 4.58, p-value =. From a(n) F2;intercross of GKxF344;GK x F344

LABEL:

QTL-Niddm3-Rat-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Galli J, Li LS, Glaser A, Ostenson CG, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H

TITLE:

Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat.

JOURNAL:

Nature genetics None None, Vol 12, pp. 31-7

ABSTRACT:

1. Nat Genet. 1996 Jan;12(1):31-7. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Galli J(1), Li LS, Glaser A, Ostenson CG, Jiao H, Fakhrai-Rad H, Jacob HJ, Lander ES, Luthman H. Author information: (1)Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden. Comment in Nat Genet. 1996 Jan;12(1):4-6. Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its aetiology remains poorly understood. We have performed a comprehensive study of the genetic basis of diabetes in the Goto-Kakizaki (GK) rat, the most widely used animal model of non-obese NIDDM. The genetic dissection of NIDDM using this model has allowed us to map three independent loci involved in the disease. In addition, we identify a major factor affecting body weight, but not glucose tolerance, on chromosome 7 and map a further 10 regions that are suggestive for linkage. We conclude that NIDDM is polygenic and fasting hyperglycaemia and postprandial hyperglycaemia clearly have distinct genetic bases. PMID: 8528247 [PubMed - indexed for MEDLINE] PUBMED: 8528247
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