DESCRIPTION:

QTL Associated with Lipid level. On Chromosome 4 with a LOD score= 2.8, p-value =0.002. From a(n) of

LABEL:

QTL-Stl19-Rat-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Watanabe T, Iizuka Y, Liang YQ, Inomata H, Gotoda T, Yanai K, Isobe M, Kato N

TITLE:

Evaluation of insulin resistance linkage to rat chromosome 4 in SHR of a Japanese colony.

JOURNAL:

Biochemical and biophysical research communications None None, Vol 329, pp. 879-87

ABSTRACT:

1. Biochem Biophys Res Commun. 2005 Apr 15;329(3):879-87. Evaluation of insulin resistance linkage to rat chromosome 4 in SHR of a Japanese colony. Watanabe T(1), Iizuka Y, Liang YQ, Inomata H, Gotoda T, Yanai K, Isobe M, Kato N. Author information: (1)Department of Gene Diagnostics and Therapeutics, Research Institute, International Medical Center of Japan, Japan. The spontaneously hypertensive rat (SHR) is a model of human insulin resistance syndrome. Quantitative trait loci for cellular defects in glucose and fatty acid metabolism have been mapped to an overlapping region of rat chromosome (RNO) RNO4 in SHR of the National Institute of Health colony, where a deletion in the Cd36 gene has been implicated as the causative mutation of insulin resistance. The present study has examined the potential presence of RNO4 linkage to a series of metabolic phenotypes in F(2) progeny derived from SHR of a Japanese colony (SHR/Izm) without the Cd36 mutation. Our data demonstrate that 'major' insulin resistance gene(s) are unlikely to exist on RNO4 in SHR/Izm and in vitro phenotypes measured in isolated adipocytes do not cosegregate in the F(2) population studied. Thus, it seems to be difficult to explain the underlying genetic mechanisms of insulin resistance by a single major gene on RNO4. PMID: 15752738 [PubMed - indexed for MEDLINE] PUBMED: 15752738
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