DESCRIPTION:

QTL Associated with Lipid level. On Chromosome 4 with a LOD score= 3.57, p-value =. From a(n) of

LABEL:

QTL-Stl10-Rat-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Ogino T, Moralejo DH, Kose H, Yamada T, Matsumoto K

TITLE:

Serum leptin concentration is linked to chromosomes 2 and 6 in the OLETF rat, an animal model of type 2 diabetes with mild obesity.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society None None, Vol 14, pp. 839-44

ABSTRACT:

1. Mamm Genome. 2003 Dec;14(12):839-44. Serum leptin concentration is linked to chromosomes 2 and 6 in the OLETF rat, an animal model of type 2 diabetes with mild obesity. Ogino T(1), Moralejo DH, Kose H, Yamada T, Matsumoto K. Author information: (1)Institute for Animal Experimentation, University of Tokushima School of Medicine, Kuramoto 3, Tokushima 770-8503, Japan. Leptin is produced by adipose tissue and acts as a feedback signal to the hypothalamus controlling energy homeostasis, by reducing food consumption and increasing energy expenditure. Because serum leptin levels are highly correlated with body fat mass, they can be used as an index to predict obesity-related diseases. However, the identity of genetic factors that influence the obesity and the obesity-related metabolic disorders remains largely unknown. In this study, we performed a whole-genome scan search, using 382 F2 intercross progeny between the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an animal model for obese type 2 diabetes in human, and F344 rat, in order to identify loci responsible for the regulation of leptin and other obesity-related plasma substances. We have identified two quantitative trait loci (QTLs) contributing to serum leptin levels. These two loci, designated Olep1 [Chromosome (Chr) 2] and Olep2 (Chr 6), were homologous to those of human genome regions containing several potential candidate genes for obesity. These are fatty acid-binding protein 2 (FABP2), FABP4, and FABP5 for Olep1, and proopiomelanocortin (POMC) and glucose regulatory protein (GCKR) for Olep2. PMID: 14724732 [PubMed - indexed for MEDLINE] PUBMED: 14724732
Find other GeneSets from this publication