DESCRIPTION:

QTL Associated with Body fat amount. On Chromosome 4 with a LOD score= 4.2, p-value =. From a(n) F2 of OLETFxF344

LABEL:

QTL-Bw2-Rat-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Ogino T, Wei S, Wei K, Moralejo DH, Kose H, Mizuno A, Shima K, Sasaki Y, Yamada T, Matsumoto K

TITLE:

Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF.

JOURNAL:

Genomics None None, Vol 70, pp. 19-25

ABSTRACT:

1. Genomics. 2000 Nov 15;70(1):19-25. Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF. Ogino T(1), Wei S, Wei K, Moralejo DH, Kose H, Mizuno A, Shima K, Sasaki Y, Yamada T, Matsumoto K. Author information: (1)Department of Laboratory Medicine, Institute for Animal Experimentation, University of Tokushima School of Medicine, 3 Kuramoto, Tokushima, 770-8503, Japan. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese type 2 diabetes in human. Obesity is essential for the onset of type 2 diabetes in this rat. Our present investigation was designed to identify quantitative trait loci (QTLs) contributing to obesity by performing a whole-genome search using 214 F(2) intercross progeny between OLETF and F344 rats. We have identified six QTLs responsible for adiposity indices of fat pads on rat chromosomes 2 (Obs1 for mesenteric fat), 4 (Obs2 for retroperitoneal fat), 8 (Obs3 for mesenteric fat), 9 (Obs4 for retroperitoneal fat), and 14 (Obs5 and Obs6 for retroperitoneal fat), demonstrating that the adiposity indices of individual fat pads were under the control of different genes. As expected, the OLETF allele corresponds to increased adiposity indices for all QTLs, except for Obs3, in which the F344 allele leads to an increase in the index. Copyright 2000 Academic Press. PMID: 11087657 [PubMed - indexed for MEDLINE] PUBMED: 11087657
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