DESCRIPTION:

QTL Associated with Hormone level. On Chromosome 10 with a LOD score= 2.99, p-value =2.50E-04. From a(n) of

LABEL:

QTL-Stresp5-Rat-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Potenza MN, Brodkin ES, Joe B, Luo X, Remmers EF, Wilder RL, Nestler EJ, Gelernter J

TITLE:

Genomic regions controlling corticosterone levels in rats.

JOURNAL:

Biological psychiatry None None, Vol 55, pp. 634-41

ABSTRACT:

1. Biol Psychiatry. 2004 Mar 15;55(6):634-41. Genomic regions controlling corticosterone levels in rats. Potenza MN(1), Brodkin ES, Joe B, Luo X, Remmers EF, Wilder RL, Nestler EJ, Gelernter J. Author information: (1)Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA. BACKGROUND: The identification of genetic factors controlling stress-responsiveness should advance the understanding of susceptibility to psychiatric illness. METHODS: Rat strains, F344/NHsd and LEW/NHsd, which differ in measures of stress-responsiveness and behaviors modeling psychiatric disorders, were bred to generate F2 progeny that were used in a quantitative trait loci (QTL) analysis to identify genomic regions influencing late-afternoon corticosterone levels. RESULTS: Regions on chromosomes 4 and 10 previously identified as influencing autoimmune phenomena were the most significant QTL observed, reaching suggestive significance at the genome-wide level. Congenic animals targeting these regions with F344/NHsd deoxyribonucleic acid on a DA/Bkl genomic background demonstrated corticosterone levels approximating those of F344/NHsd rats and differing significantly from DA/Bkl rats. CONCLUSIONS: Specific genomic regions influence both corticosterone levels and stress-related disease susceptibility. These findings not only represent the first identification of QTL controlling corticosterone levels but also suggest a mechanism underlying genetic differences in stress-responsiveness. PMID: 15013833 [PubMed - indexed for MEDLINE] PUBMED: 15013833
Find other GeneSets from this publication