DESCRIPTION:

QTL Associated with Tongue tumor susceptibility. On Chromosome 4 with a LOD score= 6.88, p-value =. From a(n) intercross of WFxDA

LABEL:

QTL-Tcas3-Rat-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Tanuma J, Hiai H, Shisa H, Hirano M, Semba I, Nagaoka S, Kitano M

TITLE:

Carcinogenesis modifier loci in rat tongue are subject to frequent loss of heterozygosity.

JOURNAL:

International journal of cancer. Journal international du cancer None None, Vol 102, pp. 638-42

ABSTRACT:

1. Int J Cancer. 2002 Dec 20;102(6):638-42. Carcinogenesis modifier loci in rat tongue are subject to frequent loss of heterozygosity. Tanuma J(1), Hiai H, Shisa H, Hirano M, Semba I, Nagaoka S, Kitano M. Author information: (1)Department of Oral Pathology, Kagoshima University Dental School, Kagoshima, Japan. tanuma@dentb.hal.kagoshima-u.ac.jp Rats of the DA strain are highly susceptible to 4NQO-induced TCs, whereas WF rats are barely susceptible. In (DA x WF)F2 rats, 5 QTL, Tscc1-5, are responsible for most of the phenotypic variations, though they do not account for all of the phenotypic differences between WF and DA rats. Analysis of 40 tongue tumors >5 mm in diameter from (DA x WF)F1 rats for LOH at the Tscc loci revealed a high frequency of LOH in chromosomal regions where the Tscc2, -3 and -4 loci map. In most cases of LOH, the allele of the barely susceptible WF strain was lost, suggesting that these loci in the WF strain encode tumor-suppressor genes. Analysis of the same tumors for somatic mutations in oncogenes indicated frequent alteration of Ha-ras, which maps in the Tscc3 region, but rare mutation of the p15(INK4B) and p16(INK4A) genes or the p53 and Msh2 genes. Frequent LOH was also found on rat chromosomes 5 (RNO5) and 6 (RNO6). Tumors of large size accumulated LOH at multiple loci, suggesting the involvement of Tscc loci in tumor progression. Copyright 2002 Wiley-Liss, Inc. PMID: 12448007 [PubMed - indexed for MEDLINE] PUBMED: 12448007
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