DESCRIPTION:

QTL Associated with Mammary tumor susceptibility. On Chromosome 1 with a LOD score= 2.15, p-value =. From a(n) (WF x COP) F1 x WF backcross of WF x COP

LABEL:

QTL-Mcs3-Rat-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Shepel LA, Lan H, Haag JD, Brasic GM, Gheen ME, Simon JS, Hoff P, Newton MA, Gould MN

TITLE:

Genetic identification of multiple loci that control breast cancer susceptibility in the rat.

JOURNAL:

Genetics None None, Vol 149, pp. 289-99

ABSTRACT:

1. Genetics. 1998 May;149(1):289-99. Genetic identification of multiple loci that control breast cancer susceptibility in the rat. Shepel LA(1), Lan H, Haag JD, Brasic GM, Gheen ME, Simon JS, Hoff P, Newton MA, Gould MN. Author information: (1)Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin 53792, USA. Erratum in Genetics 1998 Jul;149(3):1627. We have used a rat model of induced mammary carcinomas in an effort to identify breast cancer susceptibility genes. Using genetic crosses between the carcinoma-resistant Copenhagen (COP) and carcinoma-sensitive Wistar-Furth rats, we have confirmed the identification of the Mcs1 locus that modulates tumor number. We have now also identified two additional loci, Mcs2 and Mcs3. These three loci map to chromosomes 2, 7, and 1, respectively, and interact additively to suppress mammary carcinoma development in the COP strain. They are responsible for a major portion of the tumor-resistant phenotype of the COP rat. No loss of heterozygosity was observed surrounding the three loci. A fourth COP locus, Mcs4, has also been identified on chromosome 8 and acts in contrast to increase the number of carcinomas. These results show that mammary carcinoma susceptibility in the COP rat is a polygenic trait. Interestingly, a polymorphism in the human genomic region homologous to the rat Mcs4 region is associated with an increased breast cancer risk in African-American women. The isolation of the Mcs genes may help elucidate novel mechanisms of carcinogenesis, provide information important for human breast cancer risk estimation, and also provide unique drug discovery targets for breast cancer prevention. PMCID: PMC1460127 PMID: 9584103 [PubMed - indexed for MEDLINE] PUBMED: 9584103
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