DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 18 with a LOD score= 3.053, p-value =. From a(n) of

LABEL:

QTL-Bp237-Rat-Chr 18

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Stoll M, Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ

TITLE:

A genomic-systems biology map for cardiovascular function.

JOURNAL:

Science (New York, N.Y.) None None, Vol 294, pp. 1723-6

ABSTRACT:

1. Science. 2001 Nov 23;294(5547):1723-6. A genomic-systems biology map for cardiovascular function. Stoll M(1), Cowley AW Jr, Tonellato PJ, Greene AS, Kaldunski ML, Roman RJ, Dumas P, Schork NJ, Wang Z, Jacob HJ. Author information: (1)Department of Physiology, Bioinformatics Research Center, and, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, USA. With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome. PMID: 11721057 [PubMed - indexed for MEDLINE] PUBMED: 11721057
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