DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 2 with a LOD score= , p-value =0.001. From a(n) of

LABEL:

QTL-Bp239-Rat-Chr 2

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Deng AY, Dene H, Rapp JP

TITLE:

Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2.

JOURNAL:

Hypertension None None, Vol 30, pp. 199-202

ABSTRACT:

1. Hypertension. 1997 Aug;30(2 Pt 1):199-202. Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2. Deng AY(1), Dene H, Rapp JP. Author information: (1)Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43699-0008, USA. adeng@vortex.mco.edu A quantitative trait locus (QTL) for blood pressure was previously detected by linkage analysis in a region of rat chromosome 2 using segregating populations derived from crosses of the Dahl salt-sensitive (Dahl S) rat with rats of the Wistar-Kyoto (WKY) strain or Milan normotensive strain (MNS). Two congenic strains, S.WKY-D2N35/Nep and S.MNS-Adh/D2Mit5, have been constructed by replacing a region of chromosome 2 of the Dahl S rat with the homologous region (ie, low blood pressure QTL allele) of either the WKY or MNS rat, respectively. Systolic pressures of congenic strains S.WKY-D2N35/Nep and S.MNS-Adh/D2Mit5 fed a 2% NaCl diet for 24 days were 44+/-4.6 and 29+/-4.5 mm Hg lower, respectively, than that of the comparably treated Dahl S rats. The differences between congenic and Dahl S rats in blood pressure were highly significant (P<.001) and were corroborated by significantly (P<.001) lower ratio of heart weight to body weight in the congenic strains compared with Dahl S rats. The data from two congenic strains combined unequivocally establish the existence of a blood pressure QTL on rat chromosome 2. PMID: 9260980 [PubMed - indexed for MEDLINE] PUBMED: 9260980
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