DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 2 with a LOD score= 3, p-value =. From a(n) F2 of SHRxBN QTL Associated with Blood pressure. On Chromosome 3 with a LOD score= 4.4, p-value =. From a(n) F2 of SHRSP x WKY

LABEL:

QTL-Bp15-Rat-Chr 3

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Clark JS, Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau MT, Brosnan MJ, Devlin AM, Kelman AW, Lindpaintner K, Dominiczak AF

TITLE:

Quantitative trait loci in genetically hypertensive rats. Possible sex specificity.

JOURNAL:

Hypertension None None, Vol 28, pp. 898-906

ABSTRACT:

1. Hypertension. 1996 Nov;28(5):898-906. Quantitative trait loci in genetically hypertensive rats. Possible sex specificity. Clark JS(1), Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau MT, Brosnan MJ, Devlin AM, Kelman AW, Lindpaintner K, Dominiczak AF. Author information: (1)Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, Scotland. We performed a total genome screen in an F2 cross derived from the stroke-prone spontaneously hypertensive rat and the normotensive Wistar-Kyoto rat. Blood pressure at baseline and after 1% NaCl was measured by radiotelemetry; other phenotypes included heart rate, motor activity, left ventricle weight to body weight ratio, and vascular smooth muscle cell polyploidy, a measure of vascular hypertrophy. Quantitative trait loci affecting a given phenotype were mapped relative to microsatellite markers by using the MAPMAKER/QTL 1.1 computer package. We identified three blood pressure quantitative trait loci, two on rat chromosome 2 and one on rat chromosome 3. The quantitative trait loci close to genetic markers D2Mgh12 ("suggestive" linkage, with a maximal logarithm of the odds [LOD] score of 3.1) and D3Mgh16 (significant linkage, with a maximal LOD score of 5.6) showed possible sex specificity in the male F2 cohort only. This was confirmed by the likelihood ratio test for the difference in locus effects between the sexes. We also identified a new quantitative trait locus for LV hypertrophy on rat chromosome 14 ("suggestive" linkage, with a maximal LOD score of 3.1). The sex specificity of blood pressure quantitative trait loci will be important in designing congenic strains and substrains for fine genetic mapping and for identifying genes that regulate blood pressure. PMID: 8901842 [PubMed - indexed for MEDLINE] PUBMED: 8901842
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