DESCRIPTION:

QTL Associated with Brain/spinal cord inflammation. On Chromosome 10 with a LOD score= , p-value =2.00E-05. From a(n) of

LABEL:

QTL-Eae18-Rat-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Jagodic M, Kornek B, Weissert R, Lassmann H, Olsson T, Dahlman I

TITLE:

Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.

JOURNAL:

Immunogenetics None None, Vol 53, pp. 410-5

ABSTRACT:

1. Immunogenetics. 2001 Jul;53(5):410-5. Congenic mapping confirms a locus on rat chromosome 10 conferring strong protection against myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. Jagodic M(1), Kornek B, Weissert R, Lassmann H, Olsson T, Dahlman I. Author information: (1)Neuroimmunology Unit, Center for Molecular Medicine, L8:04, Karolinska Hospital, 17176 Stockholm, Sweden. maja.jagodic@cmm.ki.se Myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in rats closely mimics the human disease multiple sclerosis (MS). As in MS, genetic predisposition to MOG-EAE is regulated by both MHC and non-MHC genes. Based on disease regulatory influences on MOG-EAE on chromosome 10 in an F2 cross between susceptible DA and resistant ACI rats, we have now isolated this locus in a congenic rat strain to enable further dissection of disease mechanisms. This region is of particular interest, since it is homologous to human 17q for which human whole-genome scans have indicated harbors genes regulating susceptibility to MS. Phenotypic comparison between DA and the congenic DA.ACI-D10Rat2-D10Rat29 strain confirms that the chromosomal segment harbors gene(s) conferring strong protection against MOG-EAE. Furthermore, resistance to EAE in this congenic strain is associated with absence or a low level of inflammation and demyelination in the central nervous system. Levels of anti-MOG antibody isotypes did not differ between parental and congenic rats, thus an action on Th1/Th2 differentiation is unlikely. In conclusion, this is the first example of an EAE-regulating locus isolated in a congenic rat strain with retained phenotype. The mechanism by which gene(s) in the region act is still unclear and will require further studies with this congenic rat strain as a tool. PMID: 11486278 [PubMed - indexed for MEDLINE] PUBMED: 11486278
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