DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 7 with a LOD score= , p-value =1.00E-04. From a(n) of

LABEL:

QTL-Bp169-Rat-Chr 7

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Cicila GT, Garrett MR, Lee SJ, Liu J, Dene H, Rapp JP

TITLE:

High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains.

JOURNAL:

Genomics None None, Vol 72, pp. 51-60

ABSTRACT:

1. Genomics. 2001 Feb 15;72(1):51-60. High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains. Cicila GT(1), Garrett MR, Lee SJ, Liu J, Dene H, Rapp JP. Author information: (1)Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614, USA. It was previously shown using Dahl salt-sensitive (S) and salt-resistant (R) rats that a blood pressure quantitative trait locus (QTL) was present on rat chromosome 7. In the present work, this QTL was localized to a region less than 0.54 cM in size on the linkage map using a series of congenic strains. This region was contained in a single yeast artificial chromosome that was 220 kb long. This small segment still contained the primary candidate locus Cyp11b1 (11beta-hydroxylase), but the adjacent candidate genes Cyp11b2 (aldosterone synthase) and Cyp11b3 were ruled out. It is concluded that 11beta-hydroxylase, through its known genetic variants altering the production of 18-hydroxy-11-deoxy corticosterone, is very likely to account for the blood pressure QTL on chromosome 7 in the Dahl rat model of hypertension. This QTL accounts for about 23 mm Hg under the condition of 2% NaCl diet for 24 days. Copyright 2001 Academic Press. PMID: 11247666 [PubMed - indexed for MEDLINE] PUBMED: 11247666
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