DESCRIPTION:

QTL Associated with Body weight. On Chromosome 1 with a LOD score= , p-value =. From a(n) of

LABEL:

QTL-Niddm58-Rat-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Watanabe TK, Okuno S, Ono T, Yamasaki Y, Oga K, Mizoguchi-Miyakita A, Miyao H, Suzuki M, Momota H, Goto Y, Shinomiya H, Hishigaki H, Hayashi I, Asai T, Wakitani S, Takagi T, Nakamura Y, Tanigami A

TITLE:

Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat.

JOURNAL:

Clinical and experimental pharmacology & physiology None None, Vol 28, pp. 28-42

ABSTRACT:

1. Clin Exp Pharmacol Physiol. 2001 Jan-Feb;28(1-2):28-42. Single-allele correction of the Dmo1 locus in congenic animals substantially attenuates obesity, dyslipidaemia and diabetes phenotypes of the OLETF rat. Watanabe TK(1), Okuno S, Ono T, Yamasaki Y, Oga K, Mizoguchi-Miyakita A, Miyao H, Suzuki M, Momota H, Goto Y, Shinomiya H, Hishigaki H, Hayashi I, Asai T, Wakitani S, Takagi T, Nakamura Y, Tanigami A. Author information: (1)Otsuka GEN Research Institute, Otsuka Pharmaceutical Co. Ltd, Tokushima, Japan. watanabe@otsuka.gr.jp 1. Whole-genome scans have identified Dmo1 as a major quantitative trait locus for dyslipidaemia and obesity in the Otsuka Long Evans Tokushima Fatty (OLETF) rat. 2. We have produced congenic rats for the Dmo1 locus through successive back-cross breeding with diabetic OLETF rats. Marker-assisted speed congenic protocols were applied to efficiently transfer chromosomal segments from non-diabetic Brown Norway (BN) rats into the OLETF background. 3. In the fourth generation of congenic animals, we observed a substantial therapeutic effect of the Dmo1 locus on lipid metabolism, obesity control and plasma glucose homeostasis. 4. We have concluded that Dmo1 primarily affects lipid homeostasis, obesity control and/or glucose homeostasis at fasting and is secondarily involved in glucose homeostasis after loading. 5. The results of the present study show that single-allele correction of a genetic defect of the Dmo1 locus can generate a substantial therapeutic effect, despite the complex polygenic nature of type II diabetic syndromes. PMID: 11153534 [PubMed - indexed for MEDLINE] PUBMED: 11153534
Find other GeneSets from this publication