DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 2 with a LOD score= , p-value =0.05. From a(n) intercross of

LABEL:

QTL-Bp74-Rat-Chr 2

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Garrett MR, Rapp JP

TITLE:

Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society None None, Vol 13, pp. 41-4

ABSTRACT:

1. Mamm Genome. 2002 Jan;13(1):41-4. Multiple blood pressure QTL on rat Chromosome 2 defined by congenic Dahl rats. Garrett MR(1), Rapp JP. Author information: (1)Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo, Ohio 43614-5805, USA. Linkage analysis previously demonstrated a blood pressure quantitative trait locus (QTL) on rat Chromosome 2 (Chr 2) in crosses utilizing Dahl salt-sensitive (S) rats. The present work dissects this QTL by using congenic strains in which segments of Chr 2 from Wistar Kyoto rats (WKY) are placed on the S genetic background. Two distinct QTLs were found where one QTL was anticipated. These each accounted for a blood pressure of 15-20 mm Hg in rats fed 2% NaCl diet for 24 days. One QTL was in the <9-cM interval between D2Rat35 and D2Wox18 (Fgg), and the other was in the <7-cM interval between D2Wox18 (Fgg) and D2Mgh10. A third tentative QTL was suggested, but not clearly established, in the <3-cM interval between D2Mgh10 and D2Rat259. PMID: 11773968 [PubMed - indexed for MEDLINE] PUBMED: 11773968
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