DESCRIPTION:

QTL Associated with Blood pressure. On Chromosome 9 with a LOD score= 5, p-value =. From a(n) F2 of SS/Jr x SR/Jr

LABEL:

QTL-Bp34-Rat-Chr 9

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Rapp JP, Garrett MR, Dene H, Meng H, Hoebee B, Lathrop GM

TITLE:

Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9.

JOURNAL:

Genomics None None, Vol 51, pp. 191-6

ABSTRACT:

1. Genomics. 1998 Jul 15;51(2):191-6. Linkage analysis and construction of a congenic strain for a blood pressure QTL on rat chromosome 9. Rapp JP(1), Garrett MR, Dene H, Meng H, Hoebee B, Lathrop GM. Author information: (1)Department of Physiology and Molecular Medicine, Medical College of Ohio, Toledo 43614-5804, USA. A blood pressure quantitative trait locus was found (LOD = 5.0) on rat chromosome 9 using a large F2 population (N = 233) derived from Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats. The F2 rats were fed 8% NaCl diet for 8 weeks. A congenic strain introgressing the R low-blood-pressure QTL allele on chromosome 9 into the S strain was constructed. The congenic strain, designated S.R(chr 9), had a lower blood pressure (19 mm Hg, P < 0.0001) and lower heart weight (112 mg, P < 0.0001) than S rats (2% NaCl diet for 24 days), proving the existence of a blood pressure QTL in the congenic region of about 21 cM. PMID: 9722941 [PubMed - indexed for MEDLINE] PUBMED: 9722941
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