DESCRIPTION:

QTL Associated with Protein level. On Chromosome 17 with a LOD score= 6.1, p-value =7.10E-07. From a(n) of

LABEL:

QTL-Aocep1-Rat-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2015-06-10

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Gauguier D, Behmoaras J, Argoud K, Wilder SP, Pradines C, Bihoreau MT, Osborne-Pellegrin M, Jacob MP

TITLE:

Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta.

JOURNAL:

Hypertension None None, Vol 45, pp. 460-6

ABSTRACT:

1. Hypertension. 2005 Mar;45(3):460-6. Epub 2005 Jan 24. Chromosomal mapping of quantitative trait loci controlling elastin content in rat aorta. Gauguier D(1), Behmoaras J, Argoud K, Wilder SP, Pradines C, Bihoreau MT, Osborne-Pellegrin M, Jacob MP. Author information: (1)The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom. Extracellular matrix molecules such as elastin and collagens provide mechanical support to the vessel wall. In addition to its structural role, elastin is a regulator that maintains homeostasis through biologic signaling. Genetically determined minor modifications in elastin and collagen in the aorta could influence the onset and evolution of arterial pathology, such as hypertension and its complications. We previously demonstrated that the inbred Brown Norway (BN) rat shows an aortic elastin deficit in both abdominal and thoracic segments, partly because of a decrease in tropoelastin synthesis when compared with the LOU rat, that elastin gene polymorphisms in these strains do not significantly account for. After a genome-wide search for quantitative trait loci (QTL) influencing the aortic elastin, collagen, and cell protein contents in an F2 population derived from BN and LOU rats, we identified on chromosomes 2 and 14, 3 QTL specifically controlling elastin levels, and a further highly significant QTL on chromosome 17 linked to the level of cell proteins. We also mapped 3 highly significant QTL linked to body weight (on chromosomes 1 and 3) and heart weight (on chromosome 1) in the cross. This study demonstrates the polygenic control of the content of key components of the arterial wall. Such information represents a first step in understanding possible mechanisms involved in dysregulation of these parameters in arterial pathology. PMID: 15668357 [PubMed - indexed for MEDLINE] PUBMED: 15668357
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