1. Mamm Genome. 2006 Apr;17(4):310-21. Epub 2006 Apr 4.
Genetic identification of distinct loci controlling mammary tumor multiplicity,
latency, and aggressiveness in the rat.
Quan X(1), Laes JF, Stieber D, Rivière M, Russo J, Wedekind D, Coppieters W,
Farnir F, Georges M, Szpirer J, Szpirer C.
Author information:
(1)Université Libre de Bruxelles, Institut de Biologie et de Médecine
Moléculaires, Rue Profs Jeener & Brachet, 12, Gosselies, B-6041, Belgium.
The rat is considered an excellent model for studying human breast cancer.
Therefore, understanding the genetic basis of susceptibility to mammary cancer in
this species is of great interest. Previous studies based on crosses involving
the susceptible strain WF (crossed with the resistant strains COP or WKY) and
focusing on tumor multiplicity as the susceptibility phenotype led to the
identification of several loci that control chemically induced mammary cancer.
The present study was aimed to determine whether other loci can be identified by
analyzing crosses derived from another susceptible strain on the one hand, and by
including phenotypes other than tumor multiplicity on the other hand. A backcross
was generated between the susceptible SPRD-Cu3 strain and the resistant WKY
strain. Female progeny were genotyped with microsatellite markers covering all
rat autosomes, treated with a single dose of DMBA, and phenotyped with respect to
tumor latency, tumor multiplicity, and tumor aggressiveness. Seven loci
controlling mammary tumor development were detected. Different loci control tumor
multiplicity, latency, and aggressiveness. While some of these loci colocalize
with loci identified in crosses involving the susceptible strain WF, new loci
have been uncovered, indicating that the use of distinct susceptible and
resistant strain pairs will help in establishing a comprehensive inventory of
mammary cancer susceptibility loci.
PMID: 16596452 [PubMed - indexed for MEDLINE]
PUBMED: 16596452
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