DESCRIPTION:

89 European ancestry and African American successfully aged individuals, 227 European ancestry Alzheimers cases

LABEL:

Aging w/o Cog Decline GWAS

SCORE TYPE:

P-Value

DATE ADDED:

None

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Poduslo SE, Huang R, Spiro A 3rd

TITLE:

A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis.

JOURNAL:

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics Jan 2010, Vol 153B, pp. 114-9

ABSTRACT:

Successful aging without cognitive decline (SA) is apparent in those who escape age-related illnesses, such as cardiovascular disease and dementia. To determine whether there are protective genotypes that increase the probability of successful cognitive aging, a genome-wide screen was conducted on subjects who were 85 years of older, had MMSE scores >26, and had no major illnesses. SNP 500K microarrays were used. The data from the microarrays was analyzed versus that from Alzheimer\'s patients. Three SNPs in the gene for the low density lipoprotein receptor-related protein 1B (LRP1B) had significant P values, after Bonferroni correction. Additional SNPs were analyzed in this very large gene. Haplotypes in intron 18 were significant for successful aging versus Alzheimer\'s patients; those haplotypes were not significant when Alzheimer\'s patients versus CEPH controls were analyzed. These results suggest that haplotypes in the gene LRP1B are significant/protective for successful aging without cognitive decline. PUBMED: 19367585
Find other GeneSets from this publication