DESCRIPTION:

The relationship between DR and resveratrol treatment was examined using RNA from only head/thorax females. Canton-S female flies from the same cohort were grown on high calorie food, low calorie food and high calorie food with resveratrol. GSEA analysis showed that of the 83 KEGG categories that were statistically significant in head/thorax DR, 81% (67 pathways) were shared with resveratrol. Heatmap fold change was uploaded.

LABEL:

Resveratrol Canton-S heatmap

SCORE TYPE:

Effect

DATE ADDED:

None

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Antosh M, Fox D, Helfand SL, Cooper LN, Neretti N

TITLE:

New comparative genomics approach reveals a conserved health span signature across species.

JOURNAL:

Aging Jun 2011, Vol 3, pp. 576-83

ABSTRACT:

Environmental and genetic interventions extend health span in a range of organisms by triggering changes in different specific but complementary pathways. We investigated the gene expression changes that occur across species when health span is extended via different interventions. To perform this comparison using heterogeneous datasets from different measurement platforms and organisms, we developed a novel non-parametric methodology that can detect statistical significance of overlaps in ranked lists of genes, and estimate the number of genes with a common expression profile. By comparing genetic and environmental interventions that consistently lead to increased health span in invertebrates and vertebrates we built a conserved health span signature and described how such a signature depends on tissue type. Furthermore, we examined the relationship between calorie restriction and resveratrol administration and for the first time, identified common gene and pathway changes in calorie restriction and resveratrol in both invertebrates and mammals. Our approach can thus be used to explore and better define the relationships between highly complex biological phenomena, in this case those that affect the health and longevity. PUBMED: 21775776
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