DESCRIPTION:

For genetic interventions, ELAV-GeneSwitch-dSir2EP2300 and ELAV-GeneSwitch-DN-Dmp53259H flies were aged for 10 or 40 Days as described for the life span experiments on food containing diluent or RU486. Total RNA was isolated from at least 75 females. Fold change in differential expression is uploaded.

LABEL:

DR Canton-S heatmap

SCORE TYPE:

Effect

DATE ADDED:

None

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Antosh M, Fox D, Helfand SL, Cooper LN, Neretti N

TITLE:

New comparative genomics approach reveals a conserved health span signature across species.

JOURNAL:

Aging Jun 2011, Vol 3, pp. 576-83

ABSTRACT:

Environmental and genetic interventions extend health span in a range of organisms by triggering changes in different specific but complementary pathways. We investigated the gene expression changes that occur across species when health span is extended via different interventions. To perform this comparison using heterogeneous datasets from different measurement platforms and organisms, we developed a novel non-parametric methodology that can detect statistical significance of overlaps in ranked lists of genes, and estimate the number of genes with a common expression profile. By comparing genetic and environmental interventions that consistently lead to increased health span in invertebrates and vertebrates we built a conserved health span signature and described how such a signature depends on tissue type. Furthermore, we examined the relationship between calorie restriction and resveratrol administration and for the first time, identified common gene and pathway changes in calorie restriction and resveratrol in both invertebrates and mammals. Our approach can thus be used to explore and better define the relationships between highly complex biological phenomena, in this case those that affect the health and longevity. PUBMED: 21775776
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