GeneSet Information

Tier III GS213056 • Expression changes in the cortex from young (2 months) and old (22 months) BALB/c mice

DESCRIPTION:

Cortex and hypothalamus from three young (2 months) and three old (22 months) BALB/c mice were dissected. Gene expression changes in the hypothalamus and cortex during the aging process were examined by using high-density oligonucleotide arrays with probes for more than 11,000 genes (13,069 probe sets). Fold change was uploaded

LABEL:

BALB/c cortex

SCORE TYPE:

Effect

DATE ADDED:

None

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Jiang CH, Tsien JZ, Schultz PG, Hu Y

TITLE:

The effects of aging on gene expression in the hypothalamus and cortex of mice.

JOURNAL:

Proceedings of the National Academy of Sciences of the United States of America Feb 2001, Vol 98, pp. 1930-4

ABSTRACT:

A better understanding of the molecular effects of aging in the brain may help to reveal important aspects of organismal aging, as well as processes that lead to age-related brain dysfunction. In this study, we have examined differences in gene expression in the hypothalamus and cortex of young and aged mice by using high-density oligonucleotide arrays. A number of key genes involved in neuronal structure and signaling are differentially expressed in both the aged hypothalamus and cortex, including synaptotagmin I, cAMP-dependent protein kinase C beta, apolipoprotein E, protein phosphatase 2A, and prostaglandin D. Misregulation of these proteins may contribute to age-related memory deficits and neurodegenerative diseases. In addition, many proteases that play essential roles in regulating neuropeptide metabolism, amyloid precursor protein processing, and neuronal apoptosis are up-regulated in the aged brain and likely contribute significantly to brain aging. Finally, a subset of these genes whose expression is affected by aging are oppositely affected by exposure of mice to an enriched environment, suggesting that these genes may play important roles in learning and memory. PUBMED: 11172053
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Brain (D001921)
Peptide Hydrolases (D010447)
Memory (D008568)
Synaptotagmins (D050857)
Play and Playthings (D010988)
Environment (D004777)
Aging (D000375)
Mice (D051379)
Comprehension (D032882)
Cyclic AMP-Dependent Protein Kinases (D017868)
Protein Kinase C (D011493)
Proteins (D011506)
Role (D012380)
Protein Phosphatase 2 (D054648)
Neuropeptides (D009479)
Synaptotagmin I (D050863)
Hypothalamus (D007031)
Oligonucleotide Array Sequence Analysis (D020411)
Memory Disorders (D008569)
Amyloid (D000682)
Protein Kinases (D011494)
Learning (D007858)
Lead (D007854)
Phosphotransferases (D010770)
Apolipoproteins (D001053)
Aged (D000368)
Neurodegenerative Diseases (D019636)
Metabolism (D008660)
Apoptosis (D017209)
hypothalamus (MA:0000173)
brain (MA:0000168)
metabolic process (GO:0008152)
protein processing (GO:0016485)
aging (GO:0007568)
gene expression (GO:0010467)
learning (GO:0007612)
memory (GO:0007613)
signaling (GO:0023052)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351