GeneSet Information

Tier III GS212321 • Altered mitochondrial complex subunits detected in wild-type male C57BL/6J mouse aging brains

DESCRIPTION:

This study combines miRNA array and mass spectrometry proteomic analysis to detect variations in expression levels of miRNAs, and corresponding affects on their predicted target proteins, in the brain regions closely related to function decline with aging, such as cerebral cortex, midbrain, hippocampus, but not cerebellum, of 10-, 18-, 24- and 33-month-old Normal wild-type male C57BL/6J mice. Comparison fold change from 33 months vs. 10 months was uploaded.

LABEL:

C57BL/6J miRNA

SCORE TYPE:

Effect

THRESHOLD:

0.37 <=> 1.42

GENES IN THRESHOLD:

24

DATE ADDED:

None

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Li N, Bates DJ, An J, Terry DA, Wang E

TITLE:

Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain.

JOURNAL:

Neurobiology of aging May 2011, Vol 32, pp. 944-55

ABSTRACT:

Although significant advances have been made in the study of the molecular mechanisms controlling brain aging, post-transcriptional gene regulation in normal brain aging has yet to be explored. Our lab recently reported that predominant microRNA up-regulation is observed in liver during aging, with key microRNAs predicted to target detoxification genes. Here we examine the role of microRNA regulation in brain during the normal aging process. MicroRNA microarrays and global proteomic profiling were used to compare the brain tissues of 10-, 18-, 24-, and 33-month-old mice. Our results suggest that: (1) like liver, during aging the brain exhibits predominant microRNA up-regulation, and this trend starts in mid-life; (2) of the 70 up-regulated microRNAs, 27 are predicted to target 10 genes of mitochondrial complexes III, IV, and F0F1-ATPase, which exhibit inversely correlated expression; (3) mice of extreme longevity (33-month old) exhibit fewer microRNA expression changes from 10-month-old levels than do old adult mice (24-month old). We found unique de-regulated microRNAs shared between aging brain and aging liver, as well as brain- vs. liver-specific microRNAs during normal aging. PUBMED: 19487051
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Annotation Information

No sequence read archive data associated with this GeneSet.


Social Control, Formal (D012926)
Brain (D001921)
Phosphorylation (D010766)
Mesencephalon (D008636)
Aging (D000375)
Longevity (D008136)
Mice (D051379)
MicroRNAs (D035683)
Adult (D000328)
Spectrum Analysis (D013057)
Proteins (D011506)
Role (D012380)
Liver (D008099)
Down-Regulation (D015536)
Cerebral Cortex (D002540)
Tissues (D014024)
Up-Regulation (D015854)
Affect (D000339)
Exhibits as Topic (D005085)
Oxidative Phosphorylation (D010085)
Cerebellum (D002531)
Mass Spectrometry (D013058)
Hippocampus (D006624)
cerebral cortex (MA:0000185)
liver (MA:0000358)
midbrain (MA:0000207)
brain (MA:0000168)
cerebellum (MA:0000198)
hippocampus (MA:0000191)
no abnormal phenotype detected (MP:0002169)
oxidative phosphorylation (GO:0006119)
aging (GO:0007568)
phosphorylation (GO:0016310)

Gene List • 24 Genes

Genes in threshold: 24

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

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