GeneSet Information

Tier III GS18838 • Differentially expressed EtOH dependence genes in rat hippocampus, Upregulated

DESCRIPTION:

Assessment of differential expression of genes in the dorsal hippocampus of rats treated with 12% ethanol or tap water for 15 months helped identify ethanol-dependece genes. Uploaded here are genes upregulated during chronic ethanol treatment.

LABEL:

Rat EtOH Depend. UpReg

SCORE TYPE:

Binary

DATE ADDED:

2009-03-20

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Saito M, Smiley J, Toth R, Vadasz C

TITLE:

Microarray analysis of gene expression in rat hippocampus after chronic ethanol treatment.

JOURNAL:

Neurochemical research Oct 2002, Vol 27, pp. 1221-9

ABSTRACT:

It is thought that changes in gene expression in the brain mediate chronic ethanol-induced complex behaviors such as tolerance, dependence, and sensitization, and also relate to ethanol-induced brain toxicity. Using high-density filter-based cDNA microarrays (GeneFilters), we analyzed the expression of over 5000 genes in the dorsal hippocampus of rats treated with 12% ethanol or tap water for 15 months. Ethanol-induced changes in gene expression were particularly prominent in two groups of genes. One group consisted of oxidoreductases, including ceruloplasmin, uricase, branched-chain alpha-keto acid dehydrogenase, NADH ubiquinone oxidoreductase, P450, NAD+-isocitrate dehydrogenase, and cytochrome c oxidase, which may be related to ethanol-induced oxidative stress. The other group of genes included ADP-ribosylation factor, RAS related protein rab10, phosphatidylinositol 4-kinase, dynein-associated polypeptides, and dynamin-1, which seem to be involved in membrane trafficking. The results may reveal some of the pathways involved in ethanol-induced pathophysiological changes. PUBMED: 12462420
Find other GeneSets from this publication

Annotation Information

No sequence read archive data associated with this GeneSet.


Brain (D001921)
Animals (D000818)
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) (D042942)
Behavior (D001519)
Ceruloplasmin (D002570)
Dynamin I (D034284)
Drug Administration Schedule (D004334)
Cytochromes c (D045304)
Electron Transport Complex IV (D003576)
Microarray Analysis (D046228)
Electron Transport Complex I (D042967)
Rats, Inbred Lew (D011917)
NADH Dehydrogenase (D009245)
NAD (D009243)
Water (D014867)
Therapeutics (D013812)
ADP-Ribosylation Factors (D020727)
Peptides (D010455)
Phosphatidylinositols (D010716)
Rats (D051381)
Oxidative Stress (D018384)
Oligonucleotide Array Sequence Analysis (D020411)
Membranes (D008566)
Oxidoreductases (D010088)
DNA, Complementary (D018076)
Urate Oxidase (D014503)
Cytochromes (D003580)
Ubiquinone (D014451)
Ethanol (D000431)
1-Phosphatidylinositol 4-Kinase (D019870)
Hippocampus (D006624)
brain (MA:0000168)
hippocampus (MA:0000191)
oxidative stress (MP:0003674)
sensitization (GO:0046960)
membrane (GO:0016020)
gene expression (GO:0010467)

Gene List • 31 Genes

Uploaded As Gene Symbol Homology Score Priority LinkOuts Emphasis  

Manage GeneSets

Analyze GeneSets

Manage Accounts

GeneWeaver Links

Policies


Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351