GeneSet Information

Tier III GS1781 • Microarray analysis of mouse brain gene expression following acute ethanol treatment.

DESCRIPTION:

Differentially expressed genes in response to ethanol in both B6 and D2 mice.

LABEL:

Treadwell AcuteEtOHB6D2

SCORE TYPE:

Binary

DATE ADDED:

2008-06-09

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Treadwell JA, Singh SM

TITLE:

Microarray analysis of mouse brain gene expression following acute ethanol treatment.

JOURNAL:

Neurochemical research Feb 2004, Vol 29, pp. 357-69

ABSTRACT:

Alterations in gene expression are thought to help mediate certain effects of alcohol in the brain. We have analyzed the expression of approximately 24,000 genes using oligonucleotide microarrays to examine the brain expression profiles in two strains of inbred mice, C57BL/6J and DBA/2J, following exposure to an acute dose of ethanol. Our screen identified 61 genes responding to the ethanol treatment beyond a 1.5-fold threshold, with 46 genes altered in both mouse strains and 15 altered in only one strain. Approximately 25% of the genes were selected for confirmation by reverse transcriptase polymerase chain reaction with an 87% success rate. The genes identified have roles in cell signaling, gene regulation, and homeostasis/stress response. Although some of the genes were previously known to be ethanol responsive, we have for the most part identified novel genes involved in the acute murine brain response to ethanol. Such genes have the potential to represent candidate genes in the search to elucidate the molecular pathways mediating ethanol's effects in the brain. PUBMED: 15002731
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Annotation Information

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Social Control, Formal (D012926)
Brain (D001921)
Homeostasis (D006706)
Animals (D000818)
Species Specificity (D013045)
Negotiating (D017008)
Polymerase Chain Reaction (D016133)
Mice (D051379)
Microarray Analysis (D046228)
Central Nervous System Depressants (D002492)
Therapeutics (D013812)
Role (D012380)
Reverse Transcriptase Polymerase Chain Reaction (D020133)
RNA-Directed DNA Polymerase (D012194)
Oligonucleotide Array Sequence Analysis (D020411)
Mice, Inbred C57BL (D008810)
Mice, Inbred DBA (D008811)
Cells (D002477)
Computer Systems (D003199)
DNA-Directed RNA Polymerases (D012321)
Ethanol (D000431)
brain (MA:0000168)
cell (GO:0005623)
gene expression (GO:0010467)
signaling (GO:0023052)
response to ethanol (GO:0045471)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351