GeneSet Information

Tier III GS14966 • Upregulated gene expression in rat cortex after MDMA injection

DESCRIPTION:

Study investigates gene expression profiles of MDMA-induced genes and confirms that a single does of MDMA can cause multiple transcriptional changes. This gene set contains 19 upregulated MDMA-induced genes.

LABEL:

UpReg GenExpr MDMA

SCORE TYPE:

Binary

DATE ADDED:

2009-01-21

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Thiriet N, Ladenheim B, McCoy MT, Cadet JL

TITLE:

Analysis of ecstasy (MDMA)-induced transcriptional responses in the rat cortex.

JOURNAL:

The FASEB journal : official publication of the Federation of American Societies for Experimental Biology Dec 2002, Vol 16, pp. 1887-94

ABSTRACT:

3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is a popular drug of abuse. MDMA is pharmacologically classified as an entactogen because of its affinities to classical hallucinogens and stimulants. Oral ingestion of a single dose of the drug is associated with euphoria, elevated self-confidence, and heightened sensory awareness in humans. Evidence for neurotoxicity in the human serotonin (5-HT) system has been provided. In rats, a single injection of MDMA induces hyperthermia and formation of reactive oxygen species. These effects may cause MDMA-associated, long-term 5-HT depletion, with the cortex being quite sensitive to the biochemical effects of MDMA. It has been suggested that these MDMA effects may be associated with molecular changes in this brain region. To test these ideas, we have made use of the cDNA array analysis, which can provide a more global view of the molecular changes secondary to MDMA injections. Our results show that the genes regulated by MDMA encode proteins that belong to signaling pathways, transcription regulators, or xenobiotic metabolism. Our observations indicate that cortical cells respond to the acute administration of MDMA by modulating transcription of several genes that might lead to long-term changes in the brain. PUBMED: 12468453
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Annotation Information

No sequence read archive data associated with this GeneSet.


Eating (D004435)
Brain (D001921)
Gene Expression Regulation (D005786)
Animals (D000818)
Humans (D006801)
Reactive Oxygen Species (D017382)
Polymerase Chain Reaction (D016133)
Gene Expression Profiling (D020869)
Serotonin (D012701)
N-Methyl-3,4-methylenedioxyamphetamine (D018817)
Oxygen (D010100)
RNA, Messenger (D012333)
Proteins (D011506)
Hallucinogens (D006213)
Extracellular Matrix Proteins (D016326)
Cytoskeletal Proteins (D003598)
Euphoria (D005059)
Cerebral Cortex (D002540)
Rats (D051381)
Oligonucleotide Array Sequence Analysis (D020411)
Cells (D002477)
Transcription, Genetic (D014158)
Transcription Factors (D014157)
Lead (D007854)
Organization and Administration (D009934)
DNA, Complementary (D018076)
Fever (D005334)
Set (Psychology) (D012718)
Signal Transduction (D015398)
Awareness (D001364)
Injections (D007267)
Metabolism (D008660)
Rats, Sprague-Dawley (D017207)
Receptors, Serotonin (D011985)
brain (MA:0000168)
metabolic process (GO:0008152)
biosynthetic process (GO:0009058)
gene expression (GO:0010467)
signaling (GO:0023052)
xenobiotic metabolic process (GO:0006805)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351