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Tier III GS14918 • Upregulation of gene expression in the lateral hypothalamus of mu opioid receptor Knock out (KO) mice following administration of chronic morphine

DESCRIPTION:

This gene set comprises the 7 lateral hypothalamus genes found by the study to upregulate gene expression mu opioid receptor knockout mice during chronic morphine treatment. Background: Study subjected wild-type and mu opioid receptor knockout mice to an escalating morphine regimen to investigate whether overstimulation of mu opiod receptors impacts on lateral hypothalamus function.

LABEL:

Morphine UpReg Knockout

SCORE TYPE:

Correlation

THRESHOLD:

0 <=> 1

GENES IN THRESHOLD:

DATE ADDED:

2009-01-20

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Befort K, Filliol D, Darcq E, Ghate A, Matifas A, Lardenois A, Muller J, Thibault C, Dembele D, Poch O, Kieffer BL

TITLE:

Gene expression is altered in the lateral hypothalamus upon activation of the mu opioid receptor.

JOURNAL:

Annals of the New York Academy of Sciences None 2008, Vol 1129, pp. 175-84

ABSTRACT:

The lateral hypothalamus (LH) is a brain structure that controls hedonic properties of both natural rewards and drugs of abuse. Mu opioid receptors are known to mediate drug reward, but whether overstimulation of these receptors impacts on LH function has not been studied. Here we have used a genome-wide microarray approach to identify LH responses to chronic mu opioid receptor activation at the transcriptional level. We have subjected wild-type and mu opioid receptor knockout mice to an escalating morphine regimen, which produces severe physical dependence in wild-type but not mutant animals. We have analyzed gene profiles in LH samples using the 430A.2 Affymetrix array and identified a set of 25 genes whose expression is altered by morphine in wild-type mice only. The regulation was confirmed for a subset of these genes using real-time quantitative PCR on samples from independent treatments. Altered expression of aquaporin 4, apolipoprotein D, and prostaglandin synthase is indicative of modified LH physiology. The regulation of two signaling genes (the serum glucocorticoid kinase and the regulator of G protein signaling 4) suggests that neurotransmission is altered in LH circuitry. Finally, the downregulation of apelin may indicate a potential role for this neuropeptide in opioid signaling and hedonic homeostasis. Altogether, our study shows that chronic mu opioid receptor stimulation induces gene expression plasticity in the LH and provides a unique collection of mu opioid receptor-dependent genes that potentially contribute to alter reward processes in addictive diseases. PUBMED: 18591478
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Annotation Information

No sequence read archive data associated with this GeneSet.

Social Control, Formal (D012926)

Brain (D001921)

Gene Expression Regulation (D005786)

Homeostasis (D006706)

Animals (D000818)

Street Drugs (D013287)

Reproducibility of Results (D015203)

Polymerase Chain Reaction (D016133)

Serum (D044967)

Mice (D051379)

Physiology (D010827)

Prostaglandin-Endoperoxide Synthases (D011451)

Mice, Knockout (D018345)

Therapeutics (D013812)

Role (D012380)

Neuropeptides (D009479)

Down-Regulation (D015536)

Receptors, Opioid, mu (D017450)

Pharmaceutical Preparations (D004364)

Up-Regulation (D015854)

Hypothalamus (D007031)

Apolipoproteins D (D053399)

Mice, Inbred C57BL (D008810)

Aquaporin 4 (D051401)

Organization and Administration (D009934)

Phosphotransferases (D010770)

Apolipoproteins (D001053)

GTP-Binding Proteins (D019204)

Reward (D012201)

Morphine (D009020)

Set (Psychology) (D012718)

Receptors, Opioid (D011957)

Synaptic Transmission (D009435)

serum (MA:0002502)

hypothalamus (MA:0000173)

brain (MA:0000168)

no abnormal phenotype detected (MP:0002169)

gene expression (GO:0010467)

signaling (GO:0023052)

Gene List • 6 Genes

Genes in threshold: 6

Uploaded As	Gene Symbol Gene Symbol Entrez Ensembl Gene UniGene MGI FlyBase WormBase RGD ZFIN	Homology	Score	Priority	LinkOuts	Emphasis

GeneSet Information

Tier III GS14918 • Upregulation of gene expression in the lateral hypothalamus of mu opioid receptor Knock out (KO) mice following administration of chronic morphine

Annotation Information

Gene List • 6 Genes

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GeneSet Information

Tier III GS14918 • Upregulation of gene expression in the lateral hypothalamus of mu opioid receptor Knock out (KO) mice following administration of chronic morphine

Annotation Information

Gene List • 6 Genes

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