GeneSet Information

Tier III GS14908 • Nicotine Abstinence Genes found in Genome-wide Association Studies (GWAS)


Gene set has 67 genes associated with nicotine abstinence. Backgound: In this study, genome-wide association studies are conducted for two human cohorts, one group demonstrating nicotine dependence, and another that successfully quit smoking. The study shows that some genetic components associated with ability to quit overlap while many do not. To perform the study, DNA samples were obtained from NIH volunteers and allelic frequencies of the samples were analyzed using Affymetrix array analysis. Table S2.


Human Nic Quit Success









Drgon T, Montoya I, Johnson C, Liu QR, Walther D, Hamer D, Uhl GR


Genome-wide association for nicotine dependence and smoking cessation success in NIH research volunteers.


Molecular medicine (Cambridge, Mass.) Jan-Feb 2009, Vol 15, pp. 21-7


Phenotypes related to both nicotine dependence and ability to successfully quit smoking display substantial heritabilities in classical and molecular genetic studies. Twin studies suggest that some genetic components for dependence overlap with genetic components of ability to quit, but that many components do not overlap. Initial genome-wide association (GWA) studies have demonstrated haplotypes that distinguish nicotine-dependent from nondependent smokers. These haplotypes overlap partially with those that distinguish individuals who successfully quit smoking from those who were not able to quit smoking in clinical trials for smoking cessation. We now report novel genome-wide association results from National Institutes of Health research volunteers who reported smoking histories, symptoms of nicotine dependence, and ability to successfully quit smoking outside the context of a clinical trial. These results buttress data from several prior GWA studies. The data from these volunteers support the idea that previously reported studies of genes associated with smoking cessation success in clinical trial participants may also apply to smokers who are more or less able to initiate and sustain abstinence outside of clinical trial settings. PUBMED: 19009022
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Annotation Information

Gene Frequency (D005787)
Aptitude (D001076)
United States (D014481)
Genome, Human (D015894)
Clinical Trial (D016430)
Research Report (D058028)
National Institutes of Health (U.S.) (D009316)
Smoking (D012907)
Genome-Wide Association Study (D055106)
Research Subjects (D035842)
Smoking Cessation (D016540)
History (D006664)
Molecular Biology (D008967)
Tobacco Use Disorder (D014029)
Treatment Outcome (D016896)
Clinical Trials as Topic (D002986)
Haplotypes (D006239)
Academies and Institutes (D000047)
Set (Psychology) (D012718)
Association (D001244)
Research (D012106)
Nicotine (D009538)
Twin Study (D018486)

Gene List • 62 Genes

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