DESCRIPTION:

This gene set comprises 102 genes showing twofold changes in expression in both ethanol-treated and nicotine-treated animals compared with control animals. Background: Using a zebrafish model, study demonstrates that adult zebrafish show a dose-dependent acute conditioned place preference (CPP) reinforcement response to ethanol or nicotine. To analyze gene expression results, microarray analysis was performed using whole brain samples and 153 genes that affect ethanol and nicotine dependence were found.

LABEL:

NicotineEtOH Dependence

SCORE TYPE:

Binary

DATE ADDED:

2009-01-20

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Kily LJ, Cowe YC, Hussain O, Patel S, McElwaine S, Cotter FE, Brennan CH

TITLE:

Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways.

JOURNAL:

The Journal of experimental biology May 2008, Vol 211, pp. 1623-34

ABSTRACT:

Addiction is a complex psychiatric disorder considered to be a disease of the brain\'s natural reward reinforcement system. Repeated stimulation of the \'reward\' pathway leads to adaptive changes in gene expression and synaptic organization that reinforce drug taking and underlie long-term changes in behaviour. The primitive nature of reward reinforcement pathways and the near universal ability of abused drugs to target the same system allow drug-associated reward and reinforcement to be studied in non-mammalian species. Zebrafish have proved to be a valuable model system for the study of vertebrate development and disease. Here we demonstrate that adult zebrafish show a dose-dependent acute conditioned place preference (CPP) reinforcement response to ethanol or nicotine. Repeated exposure of adult zebrafish to either nicotine or ethanol leads to a robust CPP response that persists following 3 weeks of abstinence and in the face of adverse stimuli, a behavioural indicator of the establishment of dependence. Microarray analysis using whole brain samples from drug-treated and control zebrafish identified 1362 genes that show a significant change in expression between control and treated individuals. Of these genes, 153 are common to both ethanol- and nicotine-treated animals. These genes include members of pathways and processes implicated in drug dependence in mammalian models, revealing conservation of neuro-adaptation pathways between zebrafish and mammals. PUBMED: 18456890
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