GeneSet Information

Tier II GS136956 • weight 4 (Wght4, Published QTL Chr 5)

DESCRIPTION:

QTL associated with weight 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (132603109)

LABEL:

QTL-Wght4-Mouse-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Bennett B, Carosone-Link PJ, Lu L, Chesler EJ, Johnson TE

TITLE:

Genetics of body weight in the LXS recombinant inbred mouse strains.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Oct 2005, Vol 16, pp. 764-74

ABSTRACT:

This is the first phenotypic analysis of 75 new recombinant inbred (RI) strains derived from ILS and ISS progenitors. We analyzed body weight in two independent cohorts of female mice at various ages and in males at 60 days. Body weight is a complex trait which has been mapped in numerous crosses in rodents. The LXS RI strains displayed a large range of weights, transgressing those of the inbred progenitors, supporting the utility of this large panel for mapping traits not selected in the progenitors. Numerous QTLs for body weight mapped in single- and multilocus scans. We assessed replication between these and previously reported QTLs based on overlapping confidence intervals of published QTLs for body weight at 60 days and used meta-analyses to determine combined p values for three QTL regions located on Chromosomes 4, 5, and 11. Strain distribution patterns of microsatellite marker genotypes, weight, and other phenotypes are available on WebQTL (http://www.webqtl.org/search.html ) and allow genetic mapping of any heritable quantitative phenotype measured in these strains. We report one such analysis, correlating brain and body weights. Large reference panels of RI strains, such as the LXS, are invaluable for identifying genetic correlations, GXE (Gene X Environment) interactions, and replicating previously identified QTLs. PUBMED: 16261418
Find other GeneSets from this publication

Annotation Information

No sequence read archive data associated with this GeneSet.


Genetics (D005823)
Chromosomes (D002875)
Research Report (D058028)
Microsatellite Repeats (D018895)
Genotype (D005838)
Mice, Inbred Strains (D008815)
Rodentia (D012377)
Body Weight (D001835)
Confidence Intervals (D016001)

Gene List • 651 Genes

Uploaded As Gene Symbol Homology Score Priority LinkOuts Emphasis