DESCRIPTION:

QTL associated with viral myocarditis susceptibility locus 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (152165052)

LABEL:

QTL-Vms2-Mouse-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3710942

AUTHORS:

Aly M, Wiltshire S, Chahrour G, Osti JC, Vidal SM

TITLE:

Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis.

JOURNAL:

Genes and immunity Apr 2007, Vol 8, pp. 193-204

ABSTRACT:

The pathogenesis of viral myocarditis is a multifactorial process involving host genetics, viral genetics and the environment in which they interact. We have used a model of infection with coxsackievirus B3 (CVB3) to characterize the contribution of host genetics to viral myocarditis in mice of different genetic backgrounds but with a common H2 haplotype: A/J and B10.A-H2(a). Here we have used Evans blue dye as a quantitative biomarker for susceptibility to CVB3-induced myocarditis in addition to histopathological semiquantitative measures. We have found evidence of linkage between susceptibility to viral myocarditis and three loci. A locus on chromosome 1 centered on D1Mit200 was linked to sarcolemmal disruption in males (P=0.00005), a second locus on chromosome 4 centered on D4Mit81 was also linked to sarcolemmal disruption in males (P=0.0022). A third locus on distal chromosome 3 centered on D3Mit19 was linked to myocardial infiltration, with a logarithm of odds (LOD) score of 4.7 (P=0.0045), as well as sarcolemmal disruption in females (P=0.0015). These results provide strong evidence for the presence of loci contributing to the susceptibility of mice to viral myocarditis. PUBMED: 17287827
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