GeneSet Information

Tier II GS136903 • ventral midbrain iron content 9 (Vmbic9, Published QTL Chr 17)

DESCRIPTION:

QTL associated with ventral midbrain iron content 9. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (45448429)

LABEL:

QTL-Vmbic9-Mouse-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3036607

AUTHORS:

Jones LC, McCarthy KA, Beard JL, Keen CL, Jones BC

TITLE:

Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice.

JOURNAL:

Nutritional neuroscience Feb-Apr 2006, Vol 9, pp. 81-92

ABSTRACT:

Copper and zinc are trace nutrients essential for normal brain function, yet an excess of these elements can be toxic. It is important therefore that these metals be closely regulated. We recently conducted a quantitative trait loci (QTL) analysis to identify chromosomal regions in the mouse containing possible regulatory genes. The animals came from 15 strains of the BXD/Ty recombinant inbred (RI) strain panel and the brain regions analyzed were frontal cortex, caudate-putamen, nucleus accumbens and ventral midbrain. Several QTL were identified for copper and/or zinc, most notably on chromosomes 1, 8, 16 and 17. Genetic correlational analysis also revealed associations between these metals and dopamine, cocaine responses, saccharine preference, immune response and seizure susceptibility. Notably, the QTL on chromosome 17 is also associated with seizure susceptibility and contains the histocompatibility H2 complex. This work shows that regulation of zinc and copper is under polygenic influence and is intimately related to CNS function. Future work will reveal genes underlying the QTL and how they interact with other genes and the environment. More importantly, revelation of the genetic underpinnings of copper and zinc brain homeostasis will aid our understanding of neurological diseases that are related to copper and zinc imbalance. PUBMED: 16910173
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Annotation Information

No sequence read archive data associated with this GeneSet.


Social Control, Formal (D012926)
Brain (D001921)
Homeostasis (D006706)
Seizures (D012640)
Animals (D000818)
Forecasting (D005544)
Mesencephalon (D008636)
Environment (D004777)
Mice (D051379)
Chromosomes (D002875)
Comprehension (D032882)
Histocompatibility (D006648)
Quantitative Trait Loci (D040641)
Chromosomes, Human, Pair 17 (D002886)
Dopamine (D004298)
Iron (D007501)
Insemination, Artificial, Heterologous (D007316)
Work (D014937)
Food (D005502)
Metals (D008670)
Nucleus Accumbens (D009714)
Copper (D003300)
Cocaine (D003042)
Elements (D004602)
Zinc (D015032)
Genes, Regulator (D005809)
Association (D001244)
caudate-putamen (MA:0000893)
frontal cortex (MA:0000905)
midbrain (MA:0000207)
brain (MA:0000168)
immune response (GO:0006955)
nucleus (GO:0005634)
chromosome (GO:0005694)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351