GeneSet Information

Tier II GS136891 • voluntary alcohol consumption QTL 5 (Vacq5, Published QTL Chr 13)

DESCRIPTION:

QTL associated with voluntary alcohol consumption QTL 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (37033374)

LABEL:

QTL-Vacq5-Mouse-Chr 13

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Gill K, Boyle AE

TITLE:

Genetic analysis of alcohol intake in recombinant inbred and congenic strains derived from A/J and C57BL/6J progenitors.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society May 2005, Vol 16, pp. 319-31

ABSTRACT:

The objective of the present study was to map quantitative trait loci (QTL) for alcohol intake using A x B/B x A recombinant inbred (RI) and AcB/BcA recombinant congenic (RC) strains of mice that were independently derived from the A/J and C57BL/6J progenitors. Mice were screened for levels of alcohol consumption with four days of forced exposure to alcohol, followed by three weeks of free choice between water and a 10% alcohol solution. Alcohol consumption data previously collected for 27 A x B/B x A RI strains were reanalyzed using a larger marker set and composite interval mapping. The reanalysis found markers on Chromosome 2 (D2Mit74, 107 cM) (males and females) and on Chromosome 11 (Pmv22, 8 cM) (females only) that exceeded the threshold for significant loci, and found suggestive loci (in males) on Chromosomes 10 (D10 Mit126, 21 cM), 12 (D12Mit37, 1 cM), 15 (Pdgfb, 46.8 cM), and 16 (D16Mit125, 29 cM). An additional suggestive locus was identified in female RI mice on Chromosome 11 (D11Mit120, 47.5 cM). Composite interval mapping (CIM) analysis indicated that there was a significant association between loci at Pdgfb and D2Mit74 in both males and females. Analysis of the AcB/BcA RC strains identified 11 QTL on Chromosomes 2, 3, 5,6, 7, 8, 9, 10, 12, 13, and 15. QTL on Chromosomes 7, 10, 12, and 15 were identified in both the A x B/B x A RI and AcB/BcA RC strains of mice. Additional QTLs identified on Chromosomes 2, 3, 7, 11, and 15 overlap with those previously identified in the literature using strains of mice with a C57BL/6J progenitor. PUBMED: 16104380
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Annotation Information



Chromosomes (D002875)
Quantitative Trait Loci (D040641)
Alcohol Drinking (D000428)
Chromosomes, Human, Pair 2 (D002889)
Chromosomes, Human, Pair 11 (D002880)
Literature (D008091)
Proto-Oncogene Proteins c-sis (D020574)
Set (Psychology) (D012718)
Association (D001244)
chromosome (GO:0005694)

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