DESCRIPTION:

QTL associated with testis weight QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (20523211)

LABEL:

QTL-Twq1-Mouse-Chr 13

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1277986

AUTHORS:

Zdek V, Musilov A, Pintr J, Simkov M, Pravenec M

TITLE:

Genetic dissection of testicular weight in the mouse with the BXD recombinant inbred strains.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Jul 1998, Vol 9, pp. 503-5

ABSTRACT:

Testicular weights were studied in the mouse BXD recombinant inbred (RI) strains. These strains were derived from DBA/2J and C57BL/6J progenitors that differ significantly in their testicular weights (0.224 g +/- 0.015 vs. 0.161 g +/- 0.03, P < 0.0001). The heritability of testicular weights was calculated to be 0.53, and the minimum number of responsible effective factors was estimated to be 5.7. The total genome scanning of the BXD RI strains with over 1000 markers revealed a quantitative trait locus (QTL) on mouse Chromosome (Chr) 13 near the D13Mit3 marker (LOD score 6.9). This QTL region was designated Twq1 and associated with over 75% of genetic variability. PUBMED: 9657844
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