DESCRIPTION:

QTL associated with Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 7. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (130061274)

LABEL:

QTL-Tmevd7-Mouse-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2669609

AUTHORS:

Butterfield RJ, Roper RJ, Rhein DM, Melvold RW, Haynes L, Ma RZ, Doerge RW, Teuscher C

TITLE:

Sex-specific quantitative trait loci govern susceptibility to Theiler\'s murine encephalomyelitis virus-induced demyelination.

JOURNAL:

Genetics Mar 2003, Vol 163, pp. 1041-6

ABSTRACT:

Susceptibility to Theiler\'s murine encephalomyelitis virus-induced demyelination (TMEVD), a mouse model for multiple sclerosis (MS), is genetically controlled. Through a mouse-human comparative mapping approach, identification of candidate susceptibility loci for MS based on the location of TMEVD susceptibility loci may be possible. Composite interval mapping (CIM) identified quantitative trait loci (QTL) controlling TMEVD severity in male and female backcross populations derived from susceptible DBA/2J and resistant BALBc/ByJ mice. We report QTL on chromosomes 1, 5, 15, and 16 affecting male mice. In addition, we identified two QTL in female mice located on chromosome 1. Our results support the existence of three linked sex-specific QTL on chromosome 1 with opposing effects on the severity of the clinical signs of TMEV-induced disease in male and female mice. PUBMED: 12663542
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