GeneSet Information

Tier II GS136853 • Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (Tmevd5, Published QTL Chr 11)

DESCRIPTION:

QTL associated with Theiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (89696613)

LABEL:

QTL-Tmevd5-Mouse-Chr 11

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1891239

AUTHORS:

Aubagnac S, Brahic M, Bureau JF

TITLE:

Viral load and a locus on chromosome 11 affect the late clinical disease caused by Theiler\'s virus.

JOURNAL:

Journal of virology Oct 1999, Vol 73, pp. 7965-71

ABSTRACT:

Theiler\'s virus causes a persistent infection and a demyelinating disease of mice which is a model for multiple sclerosis. Susceptibility to viral persistence maps to several loci, including the interferon gamma locus. Inactivating the gene coding for the interferon gamma receptor makes 129/Sv mice susceptible to persistent infection and clinical disease, whereas inactivating the interferon gamma gene makes C57BL/6 mice susceptible to persistent infection but not to clinical disease. This difference in phenotype is due to the difference in genetic background. Clinical disease depends on high viral load and Tmevd5, a locus on chromosome 11. These results have consequences for the identification of viruses which might be implicated in multiple sclerosis. PUBMED: 10482543
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Annotation Information

No sequence read archive data associated with this GeneSet.


Clinical Coding (D059019)
Viral Load (D019562)
Demyelinating Diseases (D003711)
Mice (D051379)
Chromosomes (D002875)
Theilovirus (D017945)
Chromosomes, Human, Pair 11 (D002880)
Multiple Sclerosis (D009103)
Sclerosis (D012598)
Encephalomyelitis (D004679)
Viruses (D014780)
Interferons (D007372)
Disease Susceptibility (D004198)
Affect (D000339)
Maus Elberfeld virus (D004680)
Infection (D007239)
Identification (Psychology) (D007062)
Maps (D019532)
CNS inflammation (MP:0006082)
chromosome (GO:0005694)
QTL map (EDAM_data:1860)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351