DESCRIPTION:

QTL associated with thymic lymphoma susceptible 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (142760661)

LABEL:

QTL-Tlsm1-Mouse-Chr 7

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-10-22

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:105954

AUTHORS:

Hiai H, Yamada Y, Shisa H, Kamoto T, Abujiang P, Lu LM

TITLE:

To be or not to be a T-lymphomas, that is determined by a dominant gene Tlsm-1 in mouse models.

JOURNAL:

Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K Apr 1997, Vol 11 Suppl 3, pp. 193-4

ABSTRACT:

A single dominant gene Tlsm-1 was found to determine the type of spontaneous lymphomas to be T in the cross between AKR/Ms and SL/Kh. Microsatellite analysis mapped Tlsm-1 at the position 61 cM from centromere of Chr. 7. Study of this segment of T-lymphoma prone AKXD Rl strains also showed association of Tlsm-1 with T-lymphomas. On the other hand, lymphoma latency was significantly shorten by a recessive gene lla of SL/Kh. By a quantitative trait analysis, lla was located in class II gene in MHC. PUBMED: 9209340
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