DESCRIPTION:

QTL associated with TNF-induced lethal shock susceptibility 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (84734943)

LABEL:

QTL-Tilss3-Mouse-Chr 17

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3713351

AUTHORS:

Wielockx B, Staelens J, Puimge L, Vanlaere I, Van Roy M, van Lint P, Van Roy F, Libert C

TITLE:

Description and mapping of the resistance of DBA/2 mice to TNF-induced lethal shock.

JOURNAL:

Journal of immunology (Baltimore, Md. : 1950) Apr 2007, Vol 178, pp. 5069-75

ABSTRACT:

In our search for genes that inhibit the inflammatory effects of TNF without diminishing its antitumor capacities we found that, compared with C57BL/6 mice, DBA/2 mice exhibit a dominant resistance to TNF-induced lethality. Tumor-bearing (C57BL/6 x DBA/2)(BXD)F(1) mice completely survived an otherwise lethal TNF/IFN-gamma-antitumor therapy with complete regression of the tumor. This was not the case for C57BL/6 mice. Genetic linkage analysis revealed that TNF resistance is linked to a major locus on distal chromosome 6 and a minor locus on chromosome 17. Compared with littermate controls, chromosome substitution mice carrying a DBA/2 chromosome 6 in a C57BL/6 background were significantly protected against TNF and TNF/IFN-gamma, albeit less so than DBA/2 mice. Definition of a critical region of 13 Mb on chromosome 6 was the highest mapping resolution obtained. Further analysis of candidate genes may provide a powerful tool to control TNF-induced pathologies in humans. PUBMED: 17404289
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