DESCRIPTION:

QTL associated with TNF-induced lethal shock susceptibility 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (108575096)

LABEL:

QTL-Tilss2-Mouse-Chr 11

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3055199

AUTHORS:

Staelens J, Wielockx B, Puimge L, Van Roy F, Gunet JL, Libert C

TITLE:

Hyporesponsiveness of SPRET/Ei mice to lethal shock induced by tumor necrosis factor and implications for a TNF-based antitumor therapy.

JOURNAL:

Proceedings of the National Academy of Sciences of the United States of America Jul 2002, Vol 99, pp. 9340-5

ABSTRACT:

Tumor necrosis factor (TNF) is a central mediator in lethal shock and an interesting cytokine for anticancer therapy. To inhibit TNF-induced lethal shock, it is important to identify protective genes. Here we demonstrate that the SPRET/Ei mouse strain, derived from Mus spretus, exhibits an extremely dominant resistance to TNF-induced lethal inflammation. An interspecific backcross experiment revealed that the TNF hyporesponse is linked to loci on chromosomes 2, 6, and 11. Treatment of inoculated tumors with TNF and IFN-gamma leads to regression and a highly reduced toxicity in (C57BL/6 x SPRET/Ei)F(1) mice. PUBMED: 12089334
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