DESCRIPTION:

QTL associated with thymic lymphoma susceptibility 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (93726231)

LABEL:

QTL-Thyls2-Mouse-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-09-27

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3042404

AUTHORS:

Kodama Y, Yoshikai Y, Tamura Y, Wakana S, Takagi R, Niwa O, Kominami R

TITLE:

The D5Mit7 locus on mouse chromosome 5 provides resistance to gamma-ray-induced but not N-methyl-N-nitrosourea-induced thymic lymphomas.

JOURNAL:

Carcinogenesis Jan 2004, Vol 25, pp. 143-8

ABSTRACT:

Susceptibility to gamma-ray induction of thymic lymphomas in mouse strains is controlled by low-penetrance genetic variant alleles. Our previous genome-wide scan of a mouse backcross between BALB/c and MSM strains suggested the existence of a BALB/c resistance locus near D5Mit5 on chromosome 5. To confirm this resistance, we produced congenic mice carrying a 28.4 cM region between D5Mit4 and D5Mit315 from the MSM parental strain on the BALB/c background. Lymphomas were induced in their progeny by gamma-ray irradiation or administration of N-methyl-N-nitrosourea (MNU), an alkylating agent. The incidence of radiogenic lymphomas was 87.5% in mice of the M/M genotype at D5Mit7, significantly higher than the 46% incidence in mice of the C/M genotype, indicating highly significant linkage between the locus and the resistance (P = 0.000054). In contrast, the frequencies of MNU-induced thymic lymphomas were similar between the two genotypes (P = 0.35 in chi2 test). These results confirm the presence of a resistance allele for gamma-ray induction of thymic lymphomas near the D5Mit7 locus and strongly suggest that this locus modifies carcinogenic risk from exposure to radiation but not to alkylating agents. PUBMED: 14514657
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