DESCRIPTION:

QTL associated with systolic blood pressure 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (35064678)

LABEL:

QTL-Sysbp2-Mouse-Chr 13

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2684017

AUTHORS:

Wright FA, O\'Connor DT, Roberts E, Kutey G, Berry CC, Yoneda LU, Timberlake D, Schlager G

TITLE:

Genome scan for blood pressure loci in mice.

JOURNAL:

Hypertension Oct 1999, Vol 34, pp. 625-30

ABSTRACT:

Hypertension is a complex trait of unknown cause in humans. Mice of the inbred strain BPH/2 serve as a rodent model of human hypertension and display elevated blood pressure compared with the hypotensive strain BPL/1. An F2 intercross of BPH/2 and BPL/1 and 2 backcrosses of BPL/1 with Mus spretus were used to perform interval linkage mapping for systolic blood pressure in a genome scan. Significant linkage was observed in the F2s on chromosome 10 (logarithm of the odds score [LOD]=4.9) and on chromosome 13 in the M spretus backcross (LOD=3.3), with additional suggestive LODs on chromosomes 2, 6, 8, and 18. In addition, several suggestive linkages were observed for phenotypes associated with human hypertension. Our study is the first reported genome-wide linkage scan for blood pressure genes in the mouse. PUBMED: 10523337
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