DESCRIPTION:

QTL associated with susceptibility to Salmonella typhimurium antigens 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (96885628)

LABEL:

QTL-Ssta5-Mouse-Chr 3

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3510707

AUTHORS:

de Souza CM, Morel L, Cabrera WH, Starobinas N, Ribeiro OG, Siqueira M, Ibaez OM, De Franco M

TITLE:

Quantitative trait loci in Chromosomes 3, 8, and 9 regulate antibody production against Salmonella flagellar antigens in the mouse.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Aug 2004, Vol 15, pp. 630-6

ABSTRACT:

Two mouse lines were produced by bidirectional selection according to the high (HIII) or low (LIII) antibody responsiveness against Salmonella flagellar antigens (Selection III). In the present work we conducted a genomewide scan to map the quantitative trait loci (QTL) involved in the antibody response regulation in these selected mice. HIII and LIII genomes were screened with microsatellite markers and those found polymorphic between the lines (146) were used for linkage analysis in F2 (HIII x LIII) intercross. Simple interval mapping analysis was performed using Mapmanager QTX software. Three highly significant QTL linked to antibody production against Salmonella flagellar antigens have been demonstrated in Chromosomes 3, 8, and 9. HIII and LIII lines differ in the resistance to several diseases, therefore, the relevance of these QTL with the genetic factors involved in infections, autoimmunity, and neoplastic disease progression is discussed. PUBMED: 15457342
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