DESCRIPTION:

QTL associated with spermatocyte heat stress resistance 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (177571382)

LABEL:

QTL-Sphsr1-Mouse-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:3579342

AUTHORS:

Namiki Y, Kon Y, Kazusa K, Asano A, Sasaki N, Agui T

TITLE:

Quantitative trait loci analysis of heat stress resistance of spermatocytes in the MRL/MpJ mouse.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Feb 2005, Vol 16, pp. 96-102

ABSTRACT:

The MRL/MpJ mouse has previously been reported to possess an interesting phenotype in which spermatocytes are resistant to the abdominal temperature heat shock. In this study genetic analysis for it was performed. The phenotypes of F2 progenies produced by mating MRL/MpJ and control strain C57BL/6 mice were not segregated into two types as parental phenotypes, suggesting that the phenotype is controlled by multiple genetic loci. Thus, quantitative trait loci (QTL) analysis was performed using 98 microsatellite markers. The weight ratio of the cryptorchid testis to the intact testis (testis weight ratio) and the Sertoli cell index were used for quantitative traits. QTL analysis revealed two significant QTLs located on Chrs 1 and 11 for testis weight ratio and one significant QTL located in the same region of Chr 1 for the Sertoli cell index. A microsatellite marker locus located in the peak of the QTL on Chr 1 did not recombine with the exonuclease 1 (Exo1) gene locus in 140 F2 progenies. Mutation of the Exo1 gene was previously reported to be responsible for metaphase-specific apoptosis (MSA) of spermatocytes in the MRL/MpJ mouse. These results raise the possibility that mutation of the Exo1 gene is responsible for both MSA and heat stress resistance of spermatocytes in the MRL/MpJ mouse. PUBMED: 15859354
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