DESCRIPTION:

QTL associated with systematic lupus erythematosus susceptibility 1b. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (169688648)

LABEL:

QTL-Sle1b-Mouse-Chr 1

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1931843

AUTHORS:

Keszei M, Detre C, Rietdijk ST, Muoz P, Romero X, Berger SB, Calpe S, Liao G, Castro W, Julien A, Wu YY, Shin DM, Sancho J, Zubiaur M, Morse HC 3rd, Morel L, Engel P, Wang N, Terhorst C

TITLE:

A novel isoform of the Ly108 gene ameliorates murine lupus.

JOURNAL:

The Journal of experimental medicine Apr 2011, Vol 208, pp. 811-22

ABSTRACT:

Studies of human systemic lupus erythematosus patients and of murine congenic mouse strains associate genes in a DNA segment on chromosome 1 with a genetic predisposition for this disease. The systematic analysis of lupus-prone congenic mouse strains suggests a role for two isoforms of the Ly108 receptor in the pathogenesis of the disease. In this study, we demonstrate that Ly108 is involved in the pathogenesis of lupus-related autoimmunity in mice. More importantly, we identified a third protein isoform, Ly108-H1, which is absent in two lupus-prone congenic animals. Introduction of an Ly108-H1-expressing transgene markedly diminishes T cell-dependent autoimmunity in congenic B6.Sle1b mice. Thus, an immune response-suppressing isoform of Ly108 can regulate the pathogenesis of lupus. PUBMED: 21422172
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