DESCRIPTION:

QTL associated with skin tumor susceptibility 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (38901191)

LABEL:

QTL-Skts3-Mouse-Chr 5

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:104791

AUTHORS:

Nagase H, Bryson S, Cordell H, Kemp CJ, Fee F, Balmain A

TITLE:

Distinct genetic loci control development of benign and malignant skin tumours in mice.

JOURNAL:

Nature genetics Aug 1995, Vol 10, pp. 424-9

ABSTRACT:

Genetic susceptibility to chemically induced skin cancer in mice is controlled by multiple unlinked genetic loci. Mus spretus mice have dominant resistance genes which confer resistance to interspecific F1 hybrids with susceptible Mus musculus strains. We have mapped three major resistance loci using a combination of Mapmaker/QTL analysis and multiple regression analysis to mouse chromosomes 5 and 7. At least two independent loci on chromosome 7 exert their effects primarily during benign tumour development and have very little influence on tumour progression. On the other hand, probably a single locus on chromosome 5 affects both early and late stages of malignancy. The results indicate that benign and malignant tumours are largely under independent genetic control. PUBMED: 7670492
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