DESCRIPTION:

QTL associated with sucrose consumption 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (39320481)

LABEL:

QTL-Scon1-Mouse-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2661413

AUTHORS:

Bachmanov AA, Reed DR, Ninomiya Y, Inoue M, Tordoff MG, Price RA, Beauchamp GK

TITLE:

Sucrose consumption in mice: major influence of two genetic loci affecting peripheral sensory responses.

JOURNAL:

Mammalian genome : official journal of the International Mammalian Genome Society Aug 1997, Vol 8, pp. 545-8

ABSTRACT:

Individual variability in sucrose consumption is prominent in humans and other species. To investigate the genetic contribution to this complex behavior, we conducted behavioral, electrophysiological, and genetic studies, using male progeny of two inbred mouse strains (C57BL/6ByJ [B6] and 129/J [129]) and their F2 hybrids. Two loci on Chromosome (Chr) 4 were responsible for over 50% of the genetic variability in sucrose intake. These loci apparently modulated intake by altering peripheral neural responses to sucrose. One locus affected the response threshold, whereas the other affected the response magnitude. These findings suggest that the majority of difference in sucrose intake between male B6 and 129 mice is due to polymorphisms of two genes that influence receptor or peripheral nervous system activity. PUBMED: 9250857
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