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Tier II GS136619 • colon tumor susceptibility 9 (Scc9, Published QTL Chr 10)

DESCRIPTION:

QTL associated with colon tumor susceptibility 9. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (115821786)

LABEL:

QTL-Scc9-Mouse-Chr 10

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:1347110

AUTHORS:

van Wezel T, Ruivenkamp CA, Stassen AP, Moen CJ, Demant P

TITLE:

Four new colon cancer susceptibility loci, Scc6 to Scc9 in the mouse.

JOURNAL:

Cancer research Sep 1999, Vol 59, pp. 4216-8

ABSTRACT:

Germ-line mutations in APC and mismatch repair genes explain only a small percentage of all colorectal cancer cases. We have used the recombinant congenic strain mouse model to find new loci that are involved in the control of susceptibility to colon cancer. Five different colon cancer susceptibility genes, Scc1-Scc5, have been described previously using the recombinant congenic strains. Two of these loci, Scc4 and Scc5, show a reciprocal, genetic interaction. Here we report the mapping of four new colon tumor susceptibility genes: (a) Scc6 on chromosome 11; (b) Scc7 on chromosome 3; (c) Scc8 on chromosome 8; and (d) Scc9 on chromosome 10. Scc7 and Scc8 show a genetic interaction; Scc7 is only detected by virtue of its interaction with Scc8. PUBMED: 10485458
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Annotation Information

No sequence read archive data associated with this GeneSet.

Germ-Line Mutation (D018095)

Colon (D003106)

Chromosomes, Human, Pair 8 (D002898)

Chromosomes, Human, Pair 3 (D002893)

Virtues (D028722)

Colorectal Neoplasms (D015179)

Mice (D051379)

DNA Mismatch Repair (D053843)

Chromosomes (D002875)

Chromosomes, Human, Pair 10 (D002879)

Research Report (D058028)

Neoplasms (D009369)

Chromosomes, Human, Pair 11 (D002880)

Colonic Neoplasms (D003110)

Mutation (D009154)

colon (MA:0000335)

mismatch repair (GO:0006298)

chromosome (GO:0005694)

QTL map (EDAM_data:1860)

Gene List • 340 Genes

Uploaded As	Gene Symbol Gene Symbol Entrez Ensembl Gene UniGene MGI FlyBase WormBase RGD ZFIN	Homology	Score	Priority	LinkOuts	Emphasis

GeneSet Information

Tier II GS136619 • colon tumor susceptibility 9 (Scc9, Published QTL Chr 10)

Annotation Information

Gene List • 340 Genes

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GeneSet Information

Tier II GS136619 • colon tumor susceptibility 9 (Scc9, Published QTL Chr 10)

Annotation Information

Gene List • 340 Genes

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