DESCRIPTION:

QTL associated with colon tumor susceptibility 13. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (59066367)

LABEL:

QTL-Scc13-Mouse-Chr 6

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2020-05-06

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:2680975

AUTHORS:

Ruivenkamp CA, Csiks T, Klous AM, van Wezel T, Demant P

TITLE:

Five new mouse susceptibility to colon cancer loci, Scc11-Scc15.

JOURNAL:

Oncogene Oct 2003, Vol 22, pp. 7258-60

ABSTRACT:

Although several genes causing familial cancer syndromes have been identified, susceptibility to sporadic cancer remains unsolved. Animal experiments have demonstrated a large number of quantitative trait loci affecting cancer susceptibility. Previously, we described in mouse strain CcS-19/Dem five susceptibility to colon cancer (Scc) loci, Scc1-Scc5 controlling tumor numbers. In the present study, we performed an independent identical mouse cross using a distinct carcinogen, azoxymethane, to induce colon tumors. We confirmed all five originally described Scc loci and detected five additional new Scc loci; Scc11-Scc15. All these loci were detected in two-way interactions. PUBMED: 14562056
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